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ea0056oc7.1 | Genomic and clinical aspects of endocrine tumours | ECE2018

Molecular classification of benign adrenocortical tumors: an integrated genomic study

Faillot Simon , Neou Mario , Espiard Stephanie , Vaczlavik Anna , Garinet Simon , Luscap-Rondof Windy , Jouinot Anne , Drougat Ludivine , Groussin Lionel , Perlemoine Karine , Rene-Corail Fernande , Ragazzon Bruno , Rizk-Rabin Marthe , Libe Rossella , Tissier Frederique , De Reynies Aurelien , Bertherat Jerome , Assie Guillaume

Benign adrenal tumors correspond to a spectrum of distinct tumors, including uni- and bilateral diseases with distinct morphological features, and various steroid hormone secretion types and levels. The aim is to study this variability at the molecular level using pan-genomic approaches.Methods: One hundred and forty six benign adrenal tumors, including adrenocortical adenomas (ACA, N=), primary macronodular adrenal hyperplasia (PMAH, N=), and primary pi...

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ea0056oc11.2 | Clinical practice in endocrine tumours: combining conventional and molecular features | ECE2018

Molecular classifiers refine the prognostic stratification of adrenocortical carcinoma

Jouinot Anne , Assie Guillaume , Fassnacht Martin , Libe Rossella , Garinet Simon , Jacob Louis , Faillot Simon , Hamzaoui Nadim , Neou Mario , Sakat Julien , Perlemoine Karine , Sibony Mathilde , Tissier Frederique , Dousset Bertrand , Sbiera Silviu , Ronchi Cristina , Kroiss Matthias , Korpershoek Esther , De Krijger Ronald , Waldmann Jens , Quinkler Marcus , Tabarin Antoine , Chabre Olivier , Coste Joel , Luconi Michaela , Mannelli Massimo , Groussin Lionel , Bertagna Xavier , Baudin Eric , Amar Laurence , Beuschlein Felix , Bertherat Jerome

Background: Adrenocortical cancer (ACC) is an aggressive tumour with heterogeneous prognosis. Pan-genomic studies identified molecular subgroups of ACC, remarkably associated with outcome. For routine prospective use, targeted molecular measures are needed, combined into reasonably easy and cheap techniques. The aim was to develop and validate different combinations of targeted molecular markers reflecting the molecular subgroup, and compare their prognostic value to standard ...

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Endocrine Abstracts

Molecular classification of benign adrenocortical tumors: an integrated genomic study

Molecular classifiers refine the prognostic stratification of adrenocortical carcinoma

BiosciAbstracts